• Erastin for Mechanistic Ferroptosis Research

  2026-08-22

  Use Erastin to model redox collapse, genotype-associated tumor vulnerability, and iron-dependent cell death with a workflow that separates ferroptosis from nonspecific toxicity. A reference study adds a practical HIF-1 and sphingolipid-rescue dimension, helping researchers design more informative oxidative stress assays.

• DAT Imaging Tracks Dopaminergic Neuron Maturation

  2026-08-22

  Goggi et al. show that longitudinal dopamine transporter PET can assess the maturation and presynaptic integration of transplanted human embryonic stem cell-derived dopaminergic neurons in a rat model of Parkinson’s disease. The study distinguishes structural differentiation from functional dopamine release and supports DAT imaging as a quantitative tool for evaluating cell-replacement therapies.

• Lithium, Exosomal Wnt10a, and Bone Regeneration

  2026-08-21

  The reference study identifies a mechanistic link between lithium treatment, Rab11a-dependent exosomal Wnt10a secretion, and β-catenin activation in bone mesenchymal stem cells. It also shows that lithium-conditioned exosomes, particularly when delivered through GelMA hydrogels, can improve osteogenic responses and bone repair in preclinical models.

• PDK4-IN-1 hydrochloride: From Hit to Assay

  2026-08-20

  PDK4-IN-1 hydrochloride is a selective pyruvate dehydrogenase kinase 4 inhibitor for connecting allosteric mechanism with measurable metabolic phenotypes. This evidence-led guide explains how to distinguish direct PDH activation from secondary changes in glycolysis, mitochondrial respiration, and disease-model behavior.

• Zoledronic Acid: Cancer and Bone Assays

  2026-08-20

  Build reproducible Zoledronic Acid workflows for cancer cell apoptosis, breast cancer models, multiple myeloma research, and osteolytic bone disease studies. The guide emphasizes formulation control, orthogonal readouts, and a careful translation of recent mechanistic assay innovations without overstating cross-disease evidence.

• Eicosapentaenoic Acid as a Translational Lever

  2026-08-19

  Eicosapentaenoic Acid (EPA) connects membrane biology, lipid oxidation, endothelial behavior, and prostaglandin signaling. This thought-leadership guide shows how to position EPA omega-3 fatty acid experiments for reproducible cardiovascular disease research while carefully distinguishing established evidence from emerging immune-translation hypotheses.

• TBK1 and Microglial Pyroptosis in Diabetic Neuropathy

  2026-08-19

  Liao et al. identify TANK-binding kinase 1 (TBK1) as a mechanistic driver of painful diabetic neuropathy by linking spinal microglial activation to NF-κB signaling, NLRP3 inflammasome activation, and pyroptosis. Genetic knockdown and pharmacological inhibition improved pain-related and peripheral nerve outcomes, supporting TBK1 as a preclinical target while leaving important questions about model specificity and clinical translation.

• Optimized GBA1 mRNA for Gaucher Disease Therapy

  2026-08-18

  The reference study develops human GBA1 mRNA designs that improve glucocerebrosidase expression, intracellular stability, and lysosomal delivery in cellular models, while demonstrating detectable enzyme activity in mouse liver and spleen after lipid nanoparticle administration. Its findings support mRNA-LNP therapy as a potential complement or alternative to enzyme replacement, although biodistribution, neurological efficacy, dosing, and long-term safety remain unresolved.

• BRD4–AKT–SIRT3 Signaling in Hyperoxic Lung Injury

  2026-08-18

  The reference study identifies BRD4 as an upstream regulator of an AKT–SIRT3 pathway that influences apoptosis, oxidative stress, and inflammation during hyperoxia-induced lung injury. Its combined cell and animal models provide a mechanistic framework for evaluating BRD4 inhibition, while also highlighting the need to distinguish genetic BRD4 silencing from effects produced by pharmacological BET compounds.

• AMD-070 Hydrochloride: CXCR4 Assay Workflows

  2026-08-17

  AMD-070 hydrochloride enables mechanism-focused studies of CXCR4-dependent migration, signaling, and receptor-blockade phenotypes. This workflow guide combines practical handling advice with a protoplast-based assay principle that helps distinguish membrane effects from genuine pathway activity.

• SAG: From Pathway Switch to Model Design

  2026-08-17

  SAG is a Smoothened receptor agonist for experimentally controlled Hedgehog signaling activation. This assay-centered guide explains how receptor-level pharmacology, orthogonal controls, dosing, and safety boundaries improve interpretation across neural, developmental, and cancer models.

• A1 and AMD3100 in Colorectal Cancer Research

  2026-08-16

  Khorramdelazad and colleagues evaluated A1, a fluorinated CXCR4 inhibitor, against AMD3100 across computational, cellular, and mouse colorectal cancer models. A1 showed stronger predicted CXCR4 binding, inhibited CT-26 proliferation and migration, and produced greater effects on tumor growth and immunosuppressive signaling than AMD3100, while remaining a preclinical candidate requiring further validation.

• PBA-Modified PAD4 Inhibitors Block NET-Driven Tumors

  2026-08-15

  The reference study developed phenylboronic acid-modified PAD4 inhibitors that preferentially interact with tumor cells while suppressing the PAD4–H3cit–NET pathway in neutrophils. Compound 5i reduced tumor growth and lung metastasis in mouse models, illustrating how tumor-directed delivery may improve the therapeutic window of PAD4 inhibition.

• Oligo (dT) 25 Beads for mRNA Workflows

  2026-08-14

  Oligo (dT) 25 Beads provide a rapid, selective route to intact polyadenylated transcripts from eukaryotic RNA, cells, or tissues. This guide translates immune-aging findings into practical mRNA capture, cDNA, RT-PCR, and sequencing workflows while emphasizing assay limits and troubleshooting.

• Carbapenemase Gene Transmission in CREC, Guangdong

  2026-08-14

  This 2025 multicenter study combined gene-location analysis, antimicrobial susceptibility testing, conjugation experiments, mobile-element screening, and strain typing to clarify how carbapenemase-encoding genes circulate in carbapenem-resistant Enterobacter cloacae. Its findings identify plasmid-associated blaNDM-1 and frequent transfer potential as central concerns for surveillance and infection-control research.

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