• Lactate as administered in these models is metabolized

  2022-02-12

  

  Lactate as administered in these models is metabolized rapidly and it appears that transient engagement of GPR81 with lactate serum concentrations in the range of moderate exercise physiology, as measured here at 3–4 mmol/L, are sufficient to suppress tissue macrophage NF-κB activation in our models

• After initial validation of the ability of Ad Cre virus

  2022-02-12

  

  After initial validation of the ability of Ad5-Cre virus to express Cre recombinase protein in glial cells in vitro and in vivo, we employed this virus to induce site-specific deletion of our target GlyT1 in the thalamus, through injection of the cKO GlyT1 mice. This transgenic line was constructed

• In conclusion we demonstrated that the

  2022-02-12

  

  In conclusion, we demonstrated that the atypical high-basal activity of the mGlu3 dihydrofolate reductase results mostly from its activation by low ambient glutamate concentrations. This is due to a unique interaction network located in the extracellular domain of the mGlu3 receptor. This network a

• Glutamate aspartate transporters or excitatory

  2022-02-12

  

  Glutamate-aspartate transporters or excitatory amino tepp mg transporters (EAATs) are essential for the maintenance of glutamate homeostasis. EAATs are widely distributed in central neurons and glial cells (Danbolt, 2001, Martinez-Lozada et al., 2011). They are driven by Na + and K+ gradients (Jian

• We confirmed a decrease in extracellular glutamate uptake an

  2022-02-12

  

  We confirmed a decrease in extracellular glutamate uptake and the presence of efflux in an endothelial cell model of oxygen-glucose deprivation (OGD), which effectively simulates the inefficient energy supply after brain injury [15], and analysed the function of endothelial EAATs and explored the ro

• Here we reported series of carbohydrate modified compounds c

  2022-02-12

  

  Here, we reported series of carbohydrate-modified compounds containing a dibromo substituted benzene ring which was derived from the red alga (). The conformation flexibility of Camptothecin and their polyol structures give them many unique biological properties as we have described earlier. More

• GIPR genes were not found

  2022-02-12

  

  GIPR genes were not found in any of the available bird genome as well as the genomes of several species of fish (Tables S3 and S4). The genomic neighborhoods surrounding the GIPR genes in species that have them was generally conserved (see Fig. 8), and like GLP2R, those fish that did have a Gipr gen

• Many studies support that Gli transcription factors

  2022-02-12

  

  Many studies support that Gli transcription factors are not solely regulated by Hh/smo signaling but are also influenced by crosstalk with other pathways, such as RAS, PI3K/AKT, transforming growth factor-b/SMAD, PKC, or extracellular signal-regulated kinase pathways which are downstream and indepen

• Gastric inhibitory polypeptide a hormone belonging to the

  2022-02-12

  

  Gastric inhibitory polypeptide, a hormone belonging to the glucagon-secretin family of peptides, exhibits protection against the neurodegeneration and also stimulates neurogenesis in adult rats in a paracrine manner (Gault and Holscher, 2008, Nyberg et al., 2005, Usdin et al., 1993). The expression

• Newt GHS R a proteins expressed in a mammalian

  2022-02-12

  

  Newt GHS-R1a proteins expressed in a mammalian cell were able to bind homologous newt ghrelin, heterologous rat and bullfrog ghrelin, and a peptidyl GHS-R1a agonist, GHSRP-6, with inducing intracellular Ca signaling. This indicates that the identified cDNA encodes the ghrelin receptor from a view of

• The GH family has potential applications in various

  2022-02-12

  

  The GH family has potential applications in various industries. A putative ORF encoding α-galactosidase, namely GalR, with a low identical match and e-value and high query coverage in the metagenome was selected because it demonstrated considerable activity. GalR shared 65% identity with the GH 27 p

• In the course of our ongoing

  2022-02-12

  

  In the course of our ongoing attempts to photolabel allosteric binding sites of γ-aminobutyric Volasertib type A (GABAA) receptors, we were met with the need for relatively large (near mg) quantities of recombinant protein. Rather than establishing a stable cell line we sought to optimise the proce

• In addition several other considerations were made for

  2022-02-12

  

  In addition, several other considerations were made for the optimization exercise. While the structural features of the endogenous ligands for long-chain fatty Ro 3306 receptors suggest obtaining orthosteric agonists with drug-like properties may be challenging, the optimization efforts were commit

• Although our knowledge of how FAs affect GLP producing

  2022-02-11

  

  Although our knowledge of how FAs affect GLP-1-producing L-cells is sparse and incomplete, increased intracellular ceramide [6], ER stress [12], and increased production of ROS [9] are indicated mediators of the lipotoxicity induced by SFA (16:0). However, the role for/interaction between these medi

• The ability of GPX and

  2022-02-11

  

  The ability of GPX4 and other selenoproteins to be selectively induced by ferroptotic stimuli suggests that the stress-induced increase in the transcription of a number of putative, “antioxidant” selenoproteins is an adaptive homeostatic, but insufficient response to prevent cell death in the face o

14952 records 473/997 page Previous Next First page 上5页 471472473474475 下5页 Last page